A beautiful day in Southern Pines, Progeria and farnesyl transferase inhibitors

The sky is blue with white fluffy clouds floating by, the air warm with a gentle breeze and I sit in the condo writing this missive, constrained by back problems. This affliction still limits my mobility but things are improving with a reduced of use of opiates for pain amelioration. In reality, things are progressing faster than hoped. Part of the time has been used to further my reading on the disease Progeria and defects in the critical nuclear protein Lamin A. This nuclear wall structural protein could be very critical in aging. It may be that Progeria can be treated with farnesyl transferase inhibitors drugs that are currently in phase three clinical trials as cancer therapeutics. Farnesyl is a precursor of cholesterol and as a greasy lipid helps hold certain proteins on the cell or nuclear membrane. For lamin, A lack of removal of this lipid adduct causes the protein to clump on the nuclear membrane causing the symptoms of this disease that mimics premature aging. The big question is whether normal aging is at least partially the result of a similar defect and could be slowed or reduced by the use of farnesyl transferase inhibitors.
http://www.progeriaresearch.org/index.shtml